8xx1

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(New page: '''Unreleased structure''' The entry 8xx1 is ON HOLD Authors: Wang, F., Cheng, W., Lv, Z., Ju, C., Ni, C. Description: The Crystal Structure of MAPKAP kinase 2 domain from Biortus [[Ca...)
Current revision (12:12, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xx1 is ON HOLD
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==The Crystal Structure of MAPKAP kinase 2 domain from Biortus==
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<StructureSection load='8xx1' size='340' side='right'caption='[[8xx1]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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Authors: Wang, F., Cheng, W., Lv, Z., Ju, C., Ni, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xx1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XX1 FirstGlance]. <br>
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Description: The Crystal Structure of MAPKAP kinase 2 domain from Biortus
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xx1 OCA], [https://pdbe.org/8xx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xx1 RCSB], [https://www.ebi.ac.uk/pdbsum/8xx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xx1 ProSAT]</span></td></tr>
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[[Category: Wang, F]]
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</table>
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[[Category: Ju, C]]
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== Function ==
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[[Category: Ni, C]]
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[https://www.uniprot.org/uniprot/MAPK2_HUMAN MAPK2_HUMAN] Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.<ref>PMID:8280084</ref> <ref>PMID:8093612</ref> <ref>PMID:8774846</ref> <ref>PMID:10383393</ref> <ref>PMID:12456657</ref> <ref>PMID:11844797</ref> <ref>PMID:12565831</ref> <ref>PMID:14499342</ref> <ref>PMID:14517288</ref> <ref>PMID:15014438</ref> <ref>PMID:15629715</ref> <ref>PMID:16456544</ref> <ref>PMID:16278218</ref> <ref>PMID:17481585</ref> <ref>PMID:18021073</ref> <ref>PMID:20932473</ref>
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[[Category: Lv, Z]]
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== References ==
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[[Category: Cheng, W]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cheng W]]
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[[Category: Ju C]]
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[[Category: Lv Z]]
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[[Category: Ni C]]
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[[Category: Wang F]]

Current revision

The Crystal Structure of MAPKAP kinase 2 domain from Biortus

PDB ID 8xx1

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