6t9e
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t9e OCA], [https://pdbe.org/6t9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t9e RCSB], [https://www.ebi.ac.uk/pdbsum/6t9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t9e ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t9e OCA], [https://pdbe.org/6t9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t9e RCSB], [https://www.ebi.ac.uk/pdbsum/6t9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t9e ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of a bispecific DutaFab in complex with human PDGF
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Categories: Homo sapiens | Large Structures | Beckmann R | Fenn S | Jensen K | Kettenberger H | Kimbung R | Logan DT | Speck J
