Carbamazepine
From Proteopedia
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| - | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1025400/Cv/ | + | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1025400/Cv/3'> |
Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.<ref name="a4">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d409411-aa9f-4f3a-a52c-fbcb0c3ec053 "Tegretol - carbamazepine suspension Tegretol - carbamazepine tablet Tegretol XR- carbamazepine tablet, extended release".] DailyMed. 16 May 2022. Retrieved 3 January 2023.</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder.<ref name="a6">PMID:30091458</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.<ref name="a7">PMID: 31318037</ref> It is not effective for absence or myoclonic seizures.<ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> See also [https://en.wikipedia.org/wiki/Carbamazepine Carbamazepine]. | Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.<ref name="a4">[https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d409411-aa9f-4f3a-a52c-fbcb0c3ec053 "Tegretol - carbamazepine suspension Tegretol - carbamazepine tablet Tegretol XR- carbamazepine tablet, extended release".] DailyMed. 16 May 2022. Retrieved 3 January 2023.</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder.<ref name="a6">PMID:30091458</ref><ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.<ref name="a7">PMID: 31318037</ref> It is not effective for absence or myoclonic seizures.<ref name="a1">[https://www.drugs.com/monograph/carbamazepine.html "Carbamazepine".] The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.</ref> See also [https://en.wikipedia.org/wiki/Carbamazepine Carbamazepine]. | ||
| - | Carbamazepine is a sodium channel blocker.<ref name="a36">PMID: 26801895</ref> It binds preferentially to voltage-gated sodium channels in their inactive conformation, which prevents repetitive and sustained firing of an action potential. | + | Carbamazepine is a sodium channel blocker.<ref name="a36">PMID: 26801895</ref> It binds preferentially to voltage-gated sodium channels (Nav) in their inactive conformation, which prevents repetitive and sustained firing of an action potential. |
| - | [[8s9c]]. | + | <scene name='10/1025400/Cv/2'>Nav1.7 with Carbamazepine</scene> ([[8s9c]]). |
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| + | <scene name='10/1025400/Cv/4'>Carbamazepine binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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References
- ↑ "Tegretol - carbamazepine suspension Tegretol - carbamazepine tablet Tegretol XR- carbamazepine tablet, extended release". DailyMed. 16 May 2022. Retrieved 3 January 2023.
- ↑ 2.0 2.1 2.2 "Carbamazepine". The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.
- ↑ Nevitt SJ, Marson AG, Weston J, Tudur Smith C. Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev. 2018 Aug 9;8(8):CD001769. PMID:30091458 doi:10.1002/14651858.CD001769.pub4
- ↑ Nevitt SJ, Marson AG, Tudur Smith C. Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev. 2019 Jul 18;7(7):CD001911. PMID:31318037 doi:10.1002/14651858.CD001911.pub4
- ↑ Rogawski MA, Löscher W, Rho JM. Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harb Perspect Med. 2016 May 2;6(5):a022780. PMID:26801895 doi:10.1101/cshperspect.a022780
