8xyk

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(New page: '''Unreleased structure''' The entry 8xyk is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures)
Current revision (18:56, 26 February 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8xyk is ON HOLD until Paper Publication
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==Structure of CXCR3 in complex with VUF10661 and Go (Full map)==
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<StructureSection load='8xyk' size='340' side='right'caption='[[8xyk]], [[Resolution|resolution]] 3.03&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xyk]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XYK FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1LW1:(3~{S})-~{N}-[(2~{S})-6-azanyl-1-(2,2-diphenylethylamino)-1-oxidanylidene-hexan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1~{H}-isoquinoline-3-carboxamide'>A1LW1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xyk OCA], [https://pdbe.org/8xyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xyk RCSB], [https://www.ebi.ac.uk/pdbsum/8xyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xyk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CXCR3_HUMAN CXCR3_HUMAN] Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling.<ref>PMID:12782716</ref> <ref>PMID:18174362</ref> <ref>PMID:24469069</ref> Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.<ref>PMID:12782716</ref> Mediates the activity of CXCL11.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Banerjee R]]
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[[Category: Ganguly M]]
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[[Category: Nureki O]]
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[[Category: Saha S]]
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[[Category: Sano FK]]
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[[Category: Sharma S]]
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[[Category: Shihoya W]]
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[[Category: Shukla AK]]

Current revision

Structure of CXCR3 in complex with VUF10661 and Go (Full map)

PDB ID 8xyk

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