8y0u
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8y0u is ON HOLD Authors: Du, M., Zeng, F. Description: dormant ribosome with STM1 Category: Unreleased Structures Category: Du, M [[Categor...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==dormant ribosome with STM1== | |
| + | <StructureSection load='8y0u' size='340' side='right'caption='[[8y0u]], [[Resolution|resolution]] 3.59Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8y0u]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y0U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.59Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y0u OCA], [https://pdbe.org/8y0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y0u RCSB], [https://www.ebi.ac.uk/pdbsum/8y0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y0u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RL2A_YEAST RL2A_YEAST] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Background: Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation under stress conditions. Stm1/SERBP1 is one such protein that anchors the 40S and 60S subunits together. Several proteins and tRNAs bind to this complex as well, yet the molecular mechanisms remain unclear. Methods: Here, we reported the cryo-EM structures of five newly identified Stm1/SERBP1-bound ribosomes. Results: These structures highlighted that eIF5A, eEF2, and tRNA might bind to dormant ribosomes under stress to avoid their own degradation, thus facilitating protein synthesis upon the restoration of growth conditions. In addition, Ribo-seq data analysis reflected the upregulation of nutrient, metabolism, and external-stimulus-related pathways in the âstm1 strain, suggesting possible regulatory roles of Stm1. Discussion: The knowledge generated from the present work will facilitate in better understanding the molecular mechanism of dormant ribosomes. | ||
| - | + | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes.,Du M, Li X, Dong W, Zeng F Front Mol Biosci. 2024 Apr 18;11:1395220. doi: 10.3389/fmolb.2024.1395220. , eCollection 2024. PMID:38698775<ref>PMID:38698775</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Du | + | <div class="pdbe-citations 8y0u" style="background-color:#fffaf0;"></div> |
| - | [[Category: Zeng | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Du M]] | ||
| + | [[Category: Zeng F]] | ||
Current revision
dormant ribosome with STM1
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