8pfq
From Proteopedia
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| - | ==RNA structure with 1- | + | ==RNA structure with 1-methylpseudouridine, P1 space group== |
<StructureSection load='8pfq' size='340' side='right'caption='[[8pfq]], [[Resolution|resolution]] 1.01Å' scene=''> | <StructureSection load='8pfq' size='340' side='right'caption='[[8pfq]], [[Resolution|resolution]] 1.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
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<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| - | All widely used mRNA vaccines against COVID-19 contain in their sequence 1-methylpseudouridine (m1Psi) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 A respectively) of one such double-stranded 12-mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the structure of 1-methyl-pseudouridine itself was determined. | + | All widely used mRNA vaccines against COVID-19 contain in their sequence 1-methylpseudouridine (m1Psi) instead of uridine. In this publication, we report two high resolution crystal structures (at up to 1.01 and 1.32 A, respectively) of one such double-stranded 12-mer RNA sequence crystallized in two crystal forms. The structures are compared with similar structures which do not contain this modification. Additionally, the X-ray structure of 1-methyl-pseudouridine itself was determined. |
| - | RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.,Nievergelt P, Berliat F, McAuley | + | RNA oligomers at atomic resolution containing 1-methylpseudouridine, an essential building block of mRNA vaccines.,Nievergelt P, Berliat F, McAuley KE, Dorgan CR, van Well RM, Thorn A, Spingler B ChemMedChem. 2024 Apr 2;19(7):e202300600. doi: 10.1002/cmdc.202300600. Epub 2024 , Feb 29. PMID:38235959<ref>PMID:38235959</ref> |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
Current revision
RNA structure with 1-methylpseudouridine, P1 space group
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