7nqb
From Proteopedia
(Difference between revisions)
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<StructureSection load='7nqb' size='340' side='right'caption='[[7nqb]], [[Resolution|resolution]] 2.01Å' scene=''> | <StructureSection load='7nqb' size='340' side='right'caption='[[7nqb]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NQB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NQB FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7nqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7nqb OCA], [https://pdbe.org/7nqb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7nqb RCSB], [https://www.ebi.ac.uk/pdbsum/7nqb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7nqb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/LACB_BOVIN LACB_BOVIN] Primary component of whey, it binds retinol and is probably involved in the transport of that molecule. | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | beta-lactoglobulin is the major component of whey. Here, the adduct formed upon the reaction of the protein with oxaliplatin (OXA) has been prepared, structurally characterized by X-ray crystallography and electrospray ionization-mass spectrometry, and evaluated as a cytotoxic agent. The data demonstrate that OXA rapidly binds beta-lactoglobulin via coordination with a Met7 side chain upon release of the oxalate ligand. The adduct is significantly more cytotoxic than the free drug and induces apoptosis in cancer cells. Overall, our results suggest that metallodrug/beta-lactoglobulin adducts can be used as anticancer agents and that the protein can be used as a metallodrug delivery system. | ||
| - | |||
| - | Protein-Based Delivery Systems for Anticancer Metallodrugs: Structure and Biological Activity of the Oxaliplatin/beta-Lactoglobulin Adduct.,Monti DM, Loreto D, Iacobucci I, Ferraro G, Pratesi A, D'Elia L, Monti M, Merlino A Pharmaceuticals (Basel). 2022 Mar 30;15(4). pii: ph15040425. doi:, 10.3390/ph15040425. PMID:35455422<ref>PMID:35455422</ref> | ||
| - | |||
| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 7nqb" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]] | *[[Beta-lactoglobulin 3D structures|Beta-lactoglobulin 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Bos taurus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ferraro G]] | [[Category: Ferraro G]] | ||
[[Category: Loreto D]] | [[Category: Loreto D]] | ||
[[Category: Merlino A]] | [[Category: Merlino A]] | ||
Current revision
X.ray structure of the oxaliplatin/beta-lactoglobulin adduct
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