7o29
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o29 OCA], [https://pdbe.org/7o29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o29 RCSB], [https://www.ebi.ac.uk/pdbsum/7o29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o29 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o29 OCA], [https://pdbe.org/7o29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o29 RCSB], [https://www.ebi.ac.uk/pdbsum/7o29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o29 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/MET14_HUMAN MET14_HUMAN] N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).[UniProtKB:Q3UIK4]<ref>PMID:24316715</ref> <ref>PMID:24407421</ref> <ref>PMID:25719671</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Current revision
Crystal structure of the human METTL3-METTL14 complex bound to Compound 20 (ADO_AD_044)
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