1s9k
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1s9k" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s9k, resolution 3.1Å" /> '''Crystal Structure of...) |
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| - | [[Image:1s9k.gif|left|200px]]<br /> | ||
| - | <applet load="1s9k" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1s9k, resolution 3.1Å" /> | ||
| - | '''Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site'''<br /> | ||
| - | == | + | ==Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site== |
| - | + | <StructureSection load='1s9k' size='340' side='right'caption='[[1s9k]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1s9k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S9K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S9K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s9k OCA], [https://pdbe.org/1s9k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s9k RCSB], [https://www.ebi.ac.uk/pdbsum/1s9k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s9k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NFAC2_HUMAN NFAC2_HUMAN] Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway.<ref>PMID:21871017</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s9/1s9k_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s9k ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Chen | + | [[Category: Chen L]] |
| - | [[Category: Stroud | + | [[Category: Stroud JC]] |
| - | [[Category: Wang | + | [[Category: Wang D]] |
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Current revision
Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
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