1qcv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:03, 17 April 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qcv.jpg|left|200px]]
 
-
<!--
+
==RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON==
-
The line below this paragraph, containing "STRUCTURE_1qcv", creates the "Structure Box" on the page.
+
<StructureSection load='1qcv' size='340' side='right'caption='[[1qcv]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1qcv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QCV FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcv OCA], [https://pdbe.org/1qcv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qcv RCSB], [https://www.ebi.ac.uk/pdbsum/1qcv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qcv ProSAT]</span></td></tr>
-
{{STRUCTURE_1qcv| PDB=1qcv | SCENE= }}
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RUBR_PYRFU RUBR_PYRFU] Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qc/1qcv_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qcv ConSurf].
 +
<div style="clear:both"></div>
-
'''RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON'''
+
==See Also==
-
 
+
*[[Rubredoxin 3D structures|Rubredoxin 3D structures]]
-
 
+
*[[Rubredoxin PDB structures|Rubredoxin PDB structures]]
-
==Overview==
+
__TOC__
-
The role of surface salt bridges in protein stabilization has been a source of controversy. Here we present the NMR structure of a hyperthermophilic rubredoxin variant (PFRD-XC4) and the thermodynamic analysis of two surface salt bridges by double mutant cycles. This analysis shows that the surface side chain to side chain salt bridge between Lys 6 and Glu 49 does not stabilize PFRD-XC4. The main chain to side chain salt bridge between the N-terminus and Glu 14 was, however, found to stabilize PFRD-XC4 by 1. 5 kcal mol(-)(1). The entropic cost of making a surface salt bridge involving the protein's backbone is reduced, since the backbone has already been immobilized upon protein folding.
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==About this Structure==
+
-
1QCV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QCV OCA].
+
-
 
+
-
==Reference==
+
-
Contribution of surface salt bridges to protein stability., Strop P, Mayo SL, Biochemistry. 2000 Feb 15;39(6):1251-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10684603 10684603]
+
[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
-
[[Category: Single protein]]
+
[[Category: Mayo SL]]
-
[[Category: Mayo, S L.]]
+
[[Category: Strop P]]
-
[[Category: Strop, P.]]
+
-
[[Category: Hyperthermophile]]
+
-
[[Category: Rubredoxin]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:26 2008''
+

Current revision

RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON

PDB ID 1qcv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qcv"
Personal tools