8t4y
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL== | |
| - | + | <StructureSection load='8t4y' size='340' side='right'caption='[[8t4y]], [[Resolution|resolution]] 3.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8t4y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T4Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.58Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t4y OCA], [https://pdbe.org/8t4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t4y RCSB], [https://www.ebi.ac.uk/pdbsum/8t4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t4y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/HCN1_HUMAN HCN1_HUMAN] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HCN1_HUMAN HCN1_HUMAN] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli.<ref>PMID:15351778</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bickel K]] | ||
| + | [[Category: Burtscher V]] | ||
| + | [[Category: Chanda B]] | ||
| + | [[Category: Chang Y]] | ||
| + | [[Category: Cowgill J]] | ||
| + | [[Category: Mount J]] | ||
| + | [[Category: Yuan P]] | ||
Current revision
Human HCN1 F186C S264C C309A bound to cAMP, reconstituted in LMNG + SPL
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Categories: Homo sapiens | Large Structures | Bickel K | Burtscher V | Chanda B | Chang Y | Cowgill J | Mount J | Yuan P
