1qh2

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[[Image:1qh2.jpg|left|200px]]
 
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==CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA==
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The line below this paragraph, containing "STRUCTURE_1qh2", creates the "Structure Box" on the page.
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<StructureSection load='1qh2' size='340' side='right'caption='[[1qh2]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QH2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [https://pdbe.org/1qh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qh2 ProSAT]</span></td></tr>
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{{STRUCTURE_1qh2| PDB=1qh2 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q40378_NICAL Q40378_NICAL]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
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'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''
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A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.,Lee MC, Scanlon MJ, Craik DJ, Anderson MA Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353<ref>PMID:10360353</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qh2" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1QH2 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Large Structures]]
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A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10360353 10360353]
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[[Category: Nicotiana alata]]
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[[Category: Protein complex]]
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[[Category: Anderson, M A.]]
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[[Category: Craik, D J.]]
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[[Category: Lee, M C.S.]]
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[[Category: Scanlon, M J.]]
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[[Category: Nicotiana alata]]
[[Category: Nicotiana alata]]
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[[Category: Potato ii trypsin inhibitor]]
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[[Category: Anderson MA]]
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[[Category: Serine proteinase inhibitor]]
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[[Category: Craik DJ]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:15:48 2008''
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[[Category: Lee MCS]]
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[[Category: Scanlon MJ]]

Current revision

CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA

PDB ID 1qh2

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