1smo

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(New page: 200px<br /> <applet load="1smo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1smo, resolution 1.47&Aring;" /> '''Crystal Structure o...)
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[[Image:1smo.gif|left|200px]]<br />
 
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<applet load="1smo" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1smo, resolution 1.47&Aring;" />
 
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'''Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .'''<br />
 
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==Overview==
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==Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .==
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The triggering receptor expressed on myeloid cells (TREM) family of single, extracellular immunoglobulin receptors includes both activating and, inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies, the Toll-like receptor initiated responses to invading pathogens allowing, the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1, amplifies the inflammation induced by both bacteria and fungi, and thus, represents a potential therapeutic target. We report the crystal structure, of the human TREM-1 extracellular domain at 1.47 A resolution. The overall, fold places it within the V-type immunoglobulin domain family and reveals, close homology with Ig domains from antibodies, T-cell receptors and other, activating receptors, such as NKp44. With the additional use of analytical, ultracentrifugation and 1H NMR spectroscopy of both human and mouse, TREM-1, we have conclusively demonstrated the monomeric state of this, extracellular ectodomain in solution and, presumably, of the TREM family, in general.
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<StructureSection load='1smo' size='340' side='right'caption='[[1smo]], [[Resolution|resolution]] 1.47&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1smo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.47&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smo OCA], [https://pdbe.org/1smo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smo RCSB], [https://www.ebi.ac.uk/pdbsum/1smo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TREM1_HUMAN TREM1_HUMAN] Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.<ref>PMID:10799849</ref> <ref>PMID:11323674</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smo ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The triggering receptor expressed on myeloid cells (TREM) family of single extracellular immunoglobulin receptors includes both activating and inhibitory isoforms whose ligands are unknown. TREM-1 activation amplifies the Toll-like receptor initiated responses to invading pathogens allowing the secretion of pro-inflammatory chemokines and cytokines. Hence, TREM-1 amplifies the inflammation induced by both bacteria and fungi, and thus represents a potential therapeutic target. We report the crystal structure of the human TREM-1 extracellular domain at 1.47 A resolution. The overall fold places it within the V-type immunoglobulin domain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other activating receptors, such as NKp44. With the additional use of analytical ultracentrifugation and 1H NMR spectroscopy of both human and mouse TREM-1, we have conclusively demonstrated the monomeric state of this extracellular ectodomain in solution and, presumably, of the TREM family in general.
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==About this Structure==
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Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.,Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:15351648<ref>PMID:15351648</ref>
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1SMO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with TLA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SMO OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A., Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wuthrich K, Wilson IA, J Mol Biol. 2004 Sep 24;342(4):1237-48. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15351648 15351648]
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</div>
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<div class="pdbe-citations 1smo" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Foss, T.R.]]
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[[Category: Foss TR]]
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[[Category: Kelker, M.S.]]
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[[Category: Kelker MS]]
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[[Category: Kelly, J.W.]]
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[[Category: Kelly JW]]
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[[Category: Peti, W.]]
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[[Category: Peti W]]
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[[Category: Teyton, L.]]
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[[Category: Teyton L]]
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[[Category: Wilson, I.A.]]
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[[Category: Wilson IA]]
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[[Category: TLA]]
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[[Category: activating receptors]]
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[[Category: innate immune system receptor]]
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[[Category: structure]]
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[[Category: trem-1]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:15:35 2007''
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Current revision

Crystal Structure of Human Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1) at 1.47 .

PDB ID 1smo

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