8s4d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist== | |
| - | + | <StructureSection load='8s4d' size='340' side='right'caption='[[8s4d]], [[Resolution|resolution]] 2.58Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8s4d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O139:H28_str._E24377A Escherichia coli O139:H28 str. E24377A] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8S4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8S4D FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.584Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=A1D5N:(3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic+acid'>A1D5N</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8s4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8s4d OCA], [https://pdbe.org/8s4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8s4d RCSB], [https://www.ebi.ac.uk/pdbsum/8s4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8s4d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APJ_HUMAN APJ_HUMAN] Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.[https://www.uniprot.org/uniprot/A7ZVB5_ECO24 A7ZVB5_ECO24] Electron-transport protein of unknown function.[ARBA:ARBA00002028] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli O139:H28 str. E24377A]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brown AJH]] | ||
| + | [[Category: Currinn H]] | ||
| + | [[Category: Schlenker O]] | ||
| + | [[Category: Solcan N]] | ||
| + | [[Category: Verdon G]] | ||
Current revision
Crystal structure of a peptidergic GPCR in complex with a small synthetic G protein-biased agonist
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