7l6a
From Proteopedia
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<StructureSection load='7l6a' size='340' side='right'caption='[[7l6a]], [[Resolution|resolution]] 2.67Å' scene=''> | <StructureSection load='7l6a' size='340' side='right'caption='[[7l6a]], [[Resolution|resolution]] 2.67Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7L6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7L6A FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.67Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.67Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6a OCA], [https://pdbe.org/7l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6a RCSB], [https://www.ebi.ac.uk/pdbsum/7l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l6a OCA], [https://pdbe.org/7l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l6a RCSB], [https://www.ebi.ac.uk/pdbsum/7l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l6a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == | + | <div style="background-color:#fffaf0;"> |
| - | + | == Publication Abstract from PubMed == | |
| + | The capsid structures of most Adeno-associated virus (AAV) serotypes, already assigned to an antigenic clade, have been previously determined. This study reports the remaining capsid structures of AAV7, AAV11, AAV12, and AAV13 determined by cryo-electron microscopy and three-dimensional image reconstruction to 2.96, 2.86, 2.54, and 2.76 A resolution, respectively. These structures complete the structural atlas of the AAV serotype capsids. AAV7 represents the first clade D capsid structure; AAV11 and AAV12 are of a currently unassigned clade that would include AAV4; and AAV13 represents the first AAV2-AAV3 hybrid clade C capsid structure. These newly determined capsid structures all exhibit the AAV capsid features including 5-fold channels, 3-fold protrusions, 2-fold depressions, and a nucleotide binding pocket with an ordered nucleotide in genome-containing capsids. However, these structures have viral proteins that display clade-specific loop conformations. This structural characterization completes our three-dimensional library of the current AAV serotypes to provide an atlas of surface loop configurations compatible with capsid assembly and amenable for future vector engineering efforts. Derived vectors could improve gene delivery success with respect to specific tissue targeting, transduction efficiency, antigenicity or receptor retargeting. | ||
| + | |||
| + | , PMID:33450892<ref>PMID:33450892</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7l6a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Adeno-associated virus 12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Agbandje-McKenna M]] | [[Category: Agbandje-McKenna M]] | ||
[[Category: Mietzsch M]] | [[Category: Mietzsch M]] | ||
Current revision
The genome-containing AAV12 capsid
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