1qtu

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[[Image:1qtu.jpg|left|200px]]
 
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==SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1==
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The line below this paragraph, containing "STRUCTURE_1qtu", creates the "Structure Box" on the page.
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<StructureSection load='1qtu' size='340' side='right'caption='[[1qtu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qtu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QTU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qtu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qtu OCA], [https://pdbe.org/1qtu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qtu RCSB], [https://www.ebi.ac.uk/pdbsum/1qtu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qtu ProSAT]</span></td></tr>
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{{STRUCTURE_1qtu| PDB=1qtu | SCENE= }}
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</table>
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== Disease ==
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'''SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1'''
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
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== Function ==
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
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==Overview==
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== Evolutionary Conservation ==
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Two related oncogenes, TCL1 and MTCP1, are overexpressed in certain T-cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T-cell receptor gene to either chromosome 14q32 or Xq28, respectively. The human oncoprotein p13MTCP1 is coded by the MTCP1 gene and its primary sequence is highly and only homologous to that of p14TCL1, the product of TCL1. These two proteins likely represent the first members of a new family of oncogenic proteins. A previous model of the three-dimensional solution structure of p13MTCP1 was determined recently using exclusively homonuclear proton two-dimensional NMR methods and, almost simultaneously, high-resolution crystal structures of p13MTCP1 and p14TCL1 appeared in the literature. In order to gain more insight into the details of the solution structure, we uniformly labeled p13MTCP1 with nitrogen-15. The refined structure benefits from 520 additional NOEs, extracted from either 15N-edited 3D experiments or homonuclear 2D NOESY recorded at 800 MHz, and from a nearly complete set of phi angular restraints. Measurements of 15N spin relaxation times and heteronuclear 15N[1H]NOEs at two magnetic field strengths provided additional insights into the dynamics of the protein backbone. On the basis of these new results, a putative binding surface for this particular class of oncogenes is discussed.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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1QTU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QTU OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qt/1qtu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==Reference==
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<text>to colour the structure by Evolutionary Conservation</text>
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Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data., Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C, J Biomol NMR. 2000 Jul;17(3):215-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10959629 10959629]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qtu ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Guignard, L.]]
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[[Category: Guignard L]]
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[[Category: Lhoste, J-M.]]
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[[Category: Lhoste J-M]]
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[[Category: Mispelter, J.]]
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[[Category: Mispelter J]]
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[[Category: Padilla, A.]]
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[[Category: Padilla A]]
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[[Category: Roumestand, C.]]
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[[Category: Roumestand C]]
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[[Category: Stern, M-H.]]
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[[Category: Stern M-H]]
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[[Category: Yang, Y-S.]]
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[[Category: Yang Y-S]]
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[[Category: Beta barrel]]
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[[Category: Gene regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:41:52 2008''
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Current revision

SOLUTION STRUCTURE OF THE ONCOPROTEIN P13MTCP1

PDB ID 1qtu

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