9ay9

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'''Unreleased structure'''
 
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The entry 9ay9 is ON HOLD
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==Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor==
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<StructureSection load='9ay9' size='340' side='right'caption='[[9ay9]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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Authors: Zeng, H., Dong, A., Li, Y., Hutchinson, A., Seitova, A., Li, Y., Gao, Y.D., Schneider, S., Siliphaivanh, P., Sloman, D., Nicholson, B., Fischer, C., Hicks, J., Brown, P.J., Arrowsmith, C.H., Edwards, A.M., Halabelian, L., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ay9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AY9 FirstGlance]. <br>
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Description: Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AHM:(2~{R},3~{R},4~{S},5~{S})-2-(4-azanyl-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[4-[(2-~{tert}-butylpyridin-3-yl)methylamino]butylsulfanylmethyl]oxolane-3,4-diol'>A1AHM</scene></td></tr>
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[[Category: Hutchinson, A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ay9 OCA], [https://pdbe.org/9ay9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ay9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ay9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ay9 ProSAT]</span></td></tr>
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[[Category: Arrowsmith, C.H]]
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</table>
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[[Category: Seitova, A]]
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== Function ==
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[[Category: Dong, A]]
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[https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref>
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[[Category: Hicks, J]]
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== References ==
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[[Category: Li, Y]]
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<references/>
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[[Category: Halabelian, L]]
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__TOC__
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[[Category: Brown, P.J]]
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</StructureSection>
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[[Category: Fischer, C]]
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[[Category: Homo sapiens]]
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[[Category: Zeng, H]]
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[[Category: Large Structures]]
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[[Category: Schneider, S]]
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[[Category: Arrowsmith CH]]
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[[Category: Nicholson, B]]
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[[Category: Brown PJ]]
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[[Category: Edwards, A.M]]
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[[Category: Dong A]]
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[[Category: Sloman, D]]
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[[Category: Edwards AM]]
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[[Category: Siliphaivanh, P]]
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[[Category: Fischer C]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Gao YD]]
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[[Category: Gao, Y.D]]
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[[Category: Halabelian L]]
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[[Category: Hicks J]]
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[[Category: Hutchinson A]]
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[[Category: Li Y]]
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[[Category: Nicholson B]]
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[[Category: Schneider S]]
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[[Category: Seitova A]]
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[[Category: Siliphaivanh P]]
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[[Category: Sloman D]]
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[[Category: Zeng H]]

Current revision

Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor

PDB ID 9ay9

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