1qxb

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[[Image:1qxb.gif|left|200px]]
 
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==NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9==
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The line below this paragraph, containing "STRUCTURE_1qxb", creates the "Structure Box" on the page.
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<StructureSection load='1qxb' size='340' side='right'caption='[[1qxb]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qxb]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QXB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDR:BETA-D-RIBOFURANOSYL'>BDR</scene></td></tr>
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{{STRUCTURE_1qxb| PDB=1qxb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxb OCA], [https://pdbe.org/1qxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qxb RCSB], [https://www.ebi.ac.uk/pdbsum/1qxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qxb ProSAT]</span></td></tr>
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</table>
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'''NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Busson R]]
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A ribose residue inserted between the 3'-OH of one nucleotide and the 5'-phosphate group of the next nucleotide, functions as a site-specific cleavage site within DNA. This extra ribose does not interrupt helix formation and it protects duplex DNA against cleavage by restriction enzymes. Cleavage can be obtained with periodate and all ribose fragments can be removed with sodium hydroxide. As a result of this, an intact natural oligodeoxynucleotide is obtained after ligation reaction, which means that site-specific cleavage and recovering of intact DNA occurs without loss of genetic information.
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[[Category: Efimtseva E]]
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[[Category: Froeyen M]]
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==About this Structure==
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[[Category: Herdewijn P]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA].
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[[Category: Kempeneers V]]
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[[Category: Lescrinier E]]
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==Reference==
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[[Category: Mikhailov S]]
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Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside., Nauwelaerts K, Vastmans K, Froeyen M, Kempeneers V, Rozenski J, Rosemeyer H, Van Aerschot A, Busson R, Lacey JC, Efimtseva E, Mikhailov S, Lescrinier E, Herdewijn P, Nucleic Acids Res. 2003 Dec 1;31(23):6758-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14627809 14627809]
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[[Category: Nauwelaerts K]]
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[[Category: Aerschot, A Van.]]
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[[Category: Rosemeyer H]]
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[[Category: Busson, R.]]
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[[Category: Rozenski J]]
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[[Category: Efimtseva, E.]]
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[[Category: Van Aerschot A]]
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[[Category: Froeyen, M.]]
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[[Category: Vastmans K]]
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[[Category: Herdewijn, P.]]
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[[Category: Kempeneers, V.]]
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[[Category: Lescrinier, E.]]
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[[Category: Mikhailov, S.]]
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[[Category: Nauwelaerts, K.]]
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[[Category: Rosemeyer, H.]]
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[[Category: Rozenski, J.]]
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[[Category: Vastmans, K.]]
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[[Category: B-helix]]
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[[Category: Backbone modification]]
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[[Category: Disaccharide nucleotide]]
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[[Category: Ribose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:48:46 2008''
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Current revision

NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9

PDB ID 1qxb

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