1qzt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:19, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1qzt.gif|left|200px]]
 
-
<!--
+
==Phosphotransacetylase from Methanosarcina thermophila==
-
The line below this paragraph, containing "STRUCTURE_1qzt", creates the "Structure Box" on the page.
+
<StructureSection load='1qzt' size='340' side='right'caption='[[1qzt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1qzt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QZT FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_1qzt| PDB=1qzt | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qzt OCA], [https://pdbe.org/1qzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qzt RCSB], [https://www.ebi.ac.uk/pdbsum/1qzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qzt ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Phosphotransacetylase from Methanosarcina thermophila'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PTAS_METTE PTAS_METTE]
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
Phosphotransacetylase (Pta) [EC 2.3.1.8] is ubiquitous in the carbon assimilation and energy-yielding pathways in anaerobic prokaryotes where it catalyzes the reversible transfer of the acetyl group from acetyl phosphate to CoA forming acetyl CoA and inorganic phosphate. The crystal structure of Pta from the methane-producing archaeon Methanosarcina thermophila, representing the first crystal structure of any Pta, was determined by multiwavelength anomalous diffraction at 2.7 A resolution. In solution and in the crystal, the enzyme forms a homodimer. Each monomer consists of two alpha/beta domains with a cleft along the domain boundary, which presumably contains the substrate binding sites. Comparison of the four monomers present in the asymmetric unit indicates substantial variations in the relative orientation of the two domains and the structure of the putative active site cleft. A search for structural homologs revealed the NADP(+)-dependent isocitrate and isopropylmalate dehydrogenases as the only homologs with a similar two-domain architecture.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qz/1qzt_consurf.spt"</scriptWhenChecked>
-
1QZT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanosarcina_thermophila Methanosarcina thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZT OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila., Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H, Structure. 2004 Apr;12(4):559-67. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15062079 15062079]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qzt ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Methanosarcina thermophila]]
[[Category: Methanosarcina thermophila]]
-
[[Category: Phosphate acetyltransferase]]
+
[[Category: Ferry JG]]
-
[[Category: Single protein]]
+
[[Category: Iyer PP]]
-
[[Category: Ferry, J G.]]
+
[[Category: Lawrence SH]]
-
[[Category: Iyer, P P.]]
+
[[Category: Luther KB]]
-
[[Category: Lawrence, S H.]]
+
[[Category: Rajashankar KR]]
-
[[Category: Luther, K B.]]
+
[[Category: Schindelin H]]
-
[[Category: Rajashankar, K R.]]
+
[[Category: Yennawar HP]]
-
[[Category: Schindelin, H.]]
+
-
[[Category: Yennawar, H P.]]
+
-
[[Category: Acetate metabolism]]
+
-
[[Category: Acetyl phosphate]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:54:12 2008''
+

Current revision

Phosphotransacetylase from Methanosarcina thermophila

PDB ID 1qzt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qzt"
Personal tools