This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


User:Sam Magnabosco/Sandbox1

From Proteopedia

< User:Sam Magnabosco(Difference between revisions)
Jump to: navigation, search
Current revision (16:00, 12 April 2024) (edit) (undo)
 
(22 intermediate revisions not shown.)
Line 1: Line 1:
=Sam's Killer DPPIV=
=Sam's Killer DPPIV=
-
<StructureSection load='6B1E' size='340' side='right' caption='Caption for this structure' scene=''>
+
<StructureSection load='6B1E' size='450' frame='true' side='right' caption='DPPIV bound to Vildagliptin' scene='10/1037491/Dppiv_beta_propellers/2'>
-
This is a default text for your page '''Sam Magnabosco/Sandbox1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
+
 
-
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
+
==Introduction==
==Introduction==
=== Function ===
=== Function ===
 +
[https://www.rcsb.org/structure/6B1E DPPIV with Vildagliptin PDB]
=== Inhibitors ===
=== Inhibitors ===
-
[[Image:DPPIV_Proteopedia_1.png|400px|Right|thumb|Figure 1. Catalytic triad of DPPIV with Vildagliptin Bound to active site (Catalytic water is shown in Red).]]
+
[[Image:DPPIV_Proteopedia_1.png|300px|Right|thumb|Figure 1. Catalytic triad of DPPIV with Vildagliptin Bound to active site (Catalytic water is shown in Red).]] Vildagliptin Inhibits DPPIV through a covalent bond to the Ser 608 of the catalytic triad.<ref name=”Berger”>PMID:30815539</ref>
== Disease ==
== Disease ==
Line 13: Line 13:
== Structural highlights ==
== Structural highlights ==
-
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+
Structural over view highlighting the catalytic domain <scene name='10/1037491/Catalytic_domain/3'>catalytic domain</scene>
 +
Scene representing all the Intxns Vildagliptin shares in the catalytic domain <scene name='10/1037491/Vildagliptin_intxns/2'>Vildaglitpin Binding pocket Intxns</scene>
 +
 +
 +
Structural over view highlighting/differentiating between the different domains of DPPIV <scene name='10/1037491/Dppiv_domains/1'>DPPIV Domains</scene>
 +
 +
An Intro movie or just a protein overview <scene name='10/1037491/Dppiv_with_vildagliptin_movie/1'>DPPIV intro movie</scene>
</StructureSection>
</StructureSection>
== References ==
== References ==
 +
<ref name=”Berger”>PMID:30815539</ref>
 +
<ref name=”Ransey”>PMID:28504306</ref>
 +
<references/>
<references/>

Current revision

Sam's Killer DPPIV

DPPIV bound to Vildagliptin

Drag the structure with the mouse to rotate

References

[2] [3]

  1. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
  2. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
  3. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

Proteopedia Page Contributors and Editors (what is this?)

Sam Magnabosco

Retrieved from "http://52.214.119.220/wiki/index.php/User:Sam_Magnabosco/Sandbox1"
Personal tools