User:Emma Edwards/Sandbox 1
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< User:Emma Edwards(Difference between revisions)
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| - | + | <StructureSection load='7ra3' size='350' side='true' caption='GIP Bound to GIP-R 7RA3' scene''> | |
| - | <StructureSection load='7ra3' size=' | + | |
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==Introduction== | ==Introduction== | ||
| + | ==Structure== | ||
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| + | Scenes to be graded: | ||
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| + | <scene name='10/1037512/Gip_ecd_pi_stacking/7'>GIP Pi Stacking to GIPR in ECD</scene> | ||
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| + | Edited: <scene name='10/1037512/Gip_ecd_pi_stacking/10'>GIP Pi stacking to GIP-R in ECD</scene> | ||
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| + | <scene name='10/1037512/Tirz_gipr_ecd_pi_stacking/1'>Tirzepatide Pi Stacking to GIPR in ECD</scene> | ||
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| + | Edited: <scene name='10/1037512/Tirz_gipr_ecd_pi_stacking/2'>Tirzepatide bound to GIP-R in extracellular domain</scene> | ||
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| + | <scene name='10/1037512/Overview_gip_gip-r/1'>Overview: GIP in GIP-R</scene> | ||
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| + | Edited: <scene name='10/1037512/Overview_gip_gip-r/2'>GIP bound to GIP-R</scene> | ||
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== Function == | == Function == | ||
===Insulin Secretion=== | ===Insulin Secretion=== | ||
| + | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232639/#:~:text=The%20major%20purpose%20of%20insulin,%2C%20muscle%2C%20and%20adipose%20tissue. Function of Insulin in Diabetes] | ||
===Weight Loss=== | ===Weight Loss=== | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | <scene name='10/1037512/Residues_1-20_crazy/10'>Residues 1-20 CRAZY2</scene> | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| + | <ref name="Ransey">PMID:28504306</ref> | ||
| + | <ref name="Bingfa">PMID:35333651</ref> | ||
<references/> | <references/> | ||
==Student Contributors== | ==Student Contributors== | ||
| - | Emma Edwards | + | Emma Edwards, Breckin Judd |
Current revision
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References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
Student Contributors
Emma Edwards, Breckin Judd
