Emily Berkman/Sandbox 1
From Proteopedia
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=Amylin with AMY3-R, 7TZF= | =Amylin with AMY3-R, 7TZF= | ||
| - | <StructureSection load='7tzf' size=' | + | <StructureSection load='7tzf' size='350' frame='true' side='right' caption='Amylin, 7TZF' scene=''> |
==Introduction== | ==Introduction== | ||
| + | Amylin<ref name="Cao">PMID:35324283</ref> is a neuroendocrine hormone found in many species. | ||
==Main Structure== | ==Main Structure== | ||
| + | Amylin is found embedded in the membrane of organisms. | ||
| - | === Structural Highlights === | + | ===Structural Highlights=== |
| + | Binds to RAMP. | ||
| - | === Important Residues === | + | <scene name='10/1037515/Calcitonin_residues_200-210/1'>Calcitonin Section</scene> |
| + | |||
| + | ===Important Residues=== | ||
| + | C2-C7 [https://en.wikipedia.org/wiki/Disulfide disulfide bond] | ||
| + | |||
| + | ==Function== | ||
| + | Amylin helps regulate glucose homeostasis. <ref name="Ransey">PMID:28504306</ref> | ||
| + | |||
| + | [[Image:t9 full 2.png|400 px|left|thumb|Figure 1. Zoomed out look at the amylin water network at the N-Terminal end.]] | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
Amylin with AMY3-R, 7TZF
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References
- ↑ Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
Student Contributors
- Emily Berkman
