User:Jack Guckien/Sandbox1

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=''GLP-1 Receptor''=
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<StructureSection load='7rg9' size='350' frame='true' side='right' caption='Tirzepatide bound to GLP-1 Receptor, 7RGP' scene='10/1037513/7rgp_-_tirzepatide_bound/1'>
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<StructureSection load='7rg9' size='350' frame='true' side='right' caption='GLP-1 Receptor, 7rg9' scene='<scene name='10/1037513/Example1/1'>TextToBeDisplayed</scene>'>
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[[Image:GLP-1R-Apo.png|400 px|left|thumb|'''Figure 1'''.GLP-1R in Apo form]]
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== Introduction ==
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== Introduction ==
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[[Image:GLP-1R-Apo.png|400 px|left|thumb|'''Figure 1'''.GLP-1R in Apo form]]
=== History ===
=== History ===
[http://ncbi.nlm.gov/pmc/articles/PMC5707151 Discovery, characterization, and clinical development of glucagon-like peptides]
[http://ncbi.nlm.gov/pmc/articles/PMC5707151 Discovery, characterization, and clinical development of glucagon-like peptides]
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== Structure ==
== Structure ==
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<scene name='10/1037513/Example1/1'>Example1Scene</scene>
===Extracellular Domain===
===Extracellular Domain===
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===Active Site===
===Active Site===
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<scene name='10/1037513/7rgp_-_tirzepatide_boundcartoo/1'>Tirzepatide Bound Overview Cartoon</scene>
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<scene name='10/1037513/7rgp_-_tirzepatide_boundsticks/1'>Tirzepatide Bound Overview Sticks</scene>
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<scene name='10/1037513/7rgp-_2aib_mutation/3'>Tirzepatide 2AIB Mutation</scene>
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<scene name='10/1037513/7rgp_-_13aib_mutation/3'>Tirzepatide 13AIB Mutation</scene>
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<scene name='10/1037513/Y1_hbond_w_q234/7'>Tirz Hbond Y1 Q234</scene>
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<scene name='10/1037513/Pi_stacking_y10_and_y145/4'>Pi Stacking Y10 (Tirzepatide) and Y145 (GLP-1R)</scene>
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<scene name='10/1037513/Glp_bound_to_glp-1r_h_bonds/3'>GLP-1 bound to GLP-1R H-bonds</scene>
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<scene name='10/1037513/Glp_bound_to_glp-1r_no_clash/2'>GLP-1 bound to GLP-1R: interactions, no steric clash</scene>
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<scene name='10/1037513/Tirz_intxn_glp-1r_steric_clash/2'>Tirzepatide bound to GLP-1R: steric clashing </scene>
==Drug Applications==
==Drug Applications==
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== References ==
== References ==
<references/>
<references/>
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<ref name="Wan">PMID:36677809</ref>

Current revision

Tirzepatide bound to GLP-1 Receptor, 7RGP

Drag the structure with the mouse to rotate

References

[1]

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Jack Guckien

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