9enw

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(New page: '''Unreleased structure''' The entry 9enw is ON HOLD until Paper Publication Authors: Beer, M., Hinchliffe, P., Spencer, J. Description: Apo GES-1 beta-Lactamase [[Category: Unreleased...)
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'''Unreleased structure'''
 
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The entry 9enw is ON HOLD until Paper Publication
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==Apo GES-1 beta-Lactamase==
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<StructureSection load='9enw' size='340' side='right'caption='[[9enw]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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Authors: Beer, M., Hinchliffe, P., Spencer, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9enw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ENW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ENW FirstGlance]. <br>
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Description: Apo GES-1 beta-Lactamase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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[[Category: Spencer, J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9enw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9enw OCA], [https://pdbe.org/9enw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9enw RCSB], [https://www.ebi.ac.uk/pdbsum/9enw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9enw ProSAT]</span></td></tr>
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[[Category: Hinchliffe, P]]
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</table>
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[[Category: Beer, M]]
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== Function ==
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[https://www.uniprot.org/uniprot/BLAG1_KLEPN BLAG1_KLEPN] Extended-spectrum beta-lactamase (ESBL) which confers resistance to penicillins, as well as first, second, third and fourth-generation cephalosporins (PubMed:10681329, PubMed:12936982, PubMed:19656947, PubMed:20696873, PubMed:29507065). Has ceftazidime-hydrolyzing activity (PubMed:10681329, PubMed:12936982, PubMed:19656947, PubMed:20696873, PubMed:29507065). Inactive against the carbapenems, imipenem, meropenem, ertapenem and doripenem (PubMed:10681329, PubMed:19656947, PubMed:29507065). However, weak hydrolytic activity with respect to imipenem has also been reported (PubMed:20696873).<ref>PMID:10681329</ref> <ref>PMID:12936982</ref> <ref>PMID:19656947</ref> <ref>PMID:20696873</ref> <ref>PMID:29507065</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Klebsiella pneumoniae]]
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[[Category: Large Structures]]
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[[Category: Beer M]]
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[[Category: Hinchliffe P]]
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[[Category: Spencer J]]

Current revision

Apo GES-1 beta-Lactamase

PDB ID 9enw

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OCA

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