9b3z
From Proteopedia
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(New page: '''Unreleased structure''' The entry 9b3z is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Rat TRPV2 E724A/D725A bound to probenecid and 2-APB== | |
| - | + | <StructureSection load='9b3z' size='340' side='right'caption='[[9b3z]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9b3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B3Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FZ4:2-aminoethyl+diphenylborinate'>FZ4</scene>, <scene name='pdbligand=PEX:1,2-DIDECANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>PEX</scene>, <scene name='pdbligand=RTO:4-(dipropylsulfamoyl)benzoic+acid'>RTO</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b3z OCA], [https://pdbe.org/9b3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b3z RCSB], [https://www.ebi.ac.uk/pdbsum/9b3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b3z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TRPV2_RAT TRPV2_RAT] Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity).<ref>PMID:10201375</ref> <ref>PMID:15249591</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Moiseenkova-Bell VY]] | ||
| + | [[Category: Pumroy RA]] | ||
| + | [[Category: Rocereta JA]] | ||
Current revision
Rat TRPV2 E724A/D725A bound to probenecid and 2-APB
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