User:Merritt Jugo/Sandbox 1

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=''Merritt's Take on DPPIV''=
=''Merritt's Take on DPPIV''=
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<StructureSection load='6B1E' size='350' frame='true' side='right' caption='Dipeptidyl Peptidase IV (6B1E)' scene='10/1037493/Beta_propeller_in_white/1'>
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<StructureSection load='6B1E' size='350' frame='true' side='right' caption='Dipeptidyl Peptidase IV (6B1E)' scene='10/1037493/Starter_dppiv_colors/10'>
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This is a default text for your page '''Merritt Jugo/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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==Introduction==
 
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The RNA lariat debranching enzyme, Dbr1, is a metallophosphoesterase that cleaves 2'-5' phosphodiester bonds within intronic lariats. <ref name="Ransey">PMID:28504306</ref>
 
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Peter piper picked a pack of pickled peppers.
 
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Previous reports have indicated that Dbr1 enzymatic activity is supported by diverse metal ions including Ni2+ , Mn2+ , Mg2+ , Fe2+ , and Zn2+ . <ref name="Ransey"/>
 
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sally sells seashells by the sea shore.
 
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ICP-AES corroborate this finding, and in vitro debranching assays with fluorescently labeled branched substrates confirm activity. <ref name="Ransey"/>
 
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==Function==
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oxyanion hole: TYR 631
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catalytic triad: SER630, HIS740, ASP708
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[[Image:DPP4_structure_wiki.png|200 px|right|thumb|Figure 1. DPPIV structure]]
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==Structural highlights==
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DPPIV, a [http://www.en.wikipedia.org/wiki/Protein_moonlighting moonlighting protein], has been implicated in many functions and diseases of the body including glucose metabolism, cardiovascular disease, the stress response, autoimmune diseases (ie HIV/AIDS), inflammation, and tumor biology.
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===Catalytic Triad===
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cleavage site (dim gray) 1-55
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The [https://en.wikipedia.org/wiki/Catalytic_triad#:~:text=A%20catalytic%20triad%20is%20a,lipases%20and%20β%2Dlactamases). Catalytic Triad] of DPP4 is Ser630, His740, Asp708.
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beta-propeller (tomato) 56-496
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cytosine rich (khaki) 351-506
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catalytic domain (medium sea green) 552-776
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<scene name='10/1037493/Starter_dppiv_colors/10'>Starter DPPIV movie with color</scene>
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===Mechanism===
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homodimer A (lavender) and B (dim gray)
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[[Image:DPPIV_Mech.png|400 px|right|thumb|Figure 2. DPPIV Mechanism]]
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<scene name='10/1037493/Homodimer/4'>Homodimer</scene>
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The mechanism for the truncation of GLP-1 using DPP4 is a covalent catalysis.
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1st Nucleophile is Oxygen on Ser630 and the 2nd Nucleophile is water.
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beta-propeller (tomato) 56-496
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<scene name='10/1037493/Beta_propeller/3'>Beta-propeller</scene>
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==Disease==
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catalytic domain (medium sea green) 552-776
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<scene name='10/1037493/Catalytic_domain/1'>Catalytic Domain</scene>
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==Relevance==
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cytosine rich region (khaki) 351-506
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<scene name='10/1037493/Cystine_rich_region/1'>Cystine-Rich Region</scene>
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==Structural highlights==
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disulfide bonds (goldenrod) 394, 385, 444, 447, 472, 454 (khaki) 315-506
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<scene name='10/1037493/Disulfide_bonds/1'>Disulfide Bonds</scene>
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___________
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Caveolin-1 binding site (ADA) 201-210 and See 630
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<scene name='10/1037493/Cav_binding/1'>cav binding site</scene>
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<scene name='10/1037493/Cav_binding_with_beta_prop/1'>cav binding with beta prop</scene>
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<scene name='10/1037493/Cav-1_overview/2'>Cav-1 Overview</scene>
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<scene name='10/1037493/Beta_propeller_in_white/7'>Beta Propeller</scene>
 
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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<scene name='10/1037493/Cav-1_overview/3'>Cav-1 Overview with caption</scene>
</StructureSection>
</StructureSection>
==References==
==References==
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<ref name="Deacon">PMID:30828317</ref>
 
<references/>
<references/>

Current revision

Merritt's Take on DPPIV

Dipeptidyl Peptidase IV (6B1E)

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References


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Merritt Jugo

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