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1rfe

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[[Image:1rfe.gif|left|200px]]
 
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==Crystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis==
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The line below this paragraph, containing "STRUCTURE_1rfe", creates the "Structure Box" on the page.
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<StructureSection load='1rfe' size='340' side='right'caption='[[1rfe]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RFE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1rfe| PDB=1rfe | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rfe OCA], [https://pdbe.org/1rfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rfe RCSB], [https://www.ebi.ac.uk/pdbsum/1rfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rfe ProSAT], [https://www.topsan.org/Proteins/TBSGC/1rfe TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O53240_MYCTU O53240_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rf/1rfe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rfe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis has been solved by SAD using seleno-methionine substituted protein. The dimeric biological assembly and the sequence and fold conservation are typical of F420 cofactor binding enzymes. Despite Rv2991 still being of unknown function, sequence and structural comparison with similar proteins enable a role to be proposed for its C-terminal stretch of residues in recognizing and orienting the substrate. In addition, the C-terminus is involved in both protein folding and determining the size of the active site cavity.
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'''Crystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis'''
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The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420 binding protein with unknown function.,Benini S, Haouz A, Proux F, Alzari P, Wilson K J Struct Biol. 2019 Mar 16. pii: S1047-8477(19)30051-6. doi:, 10.1016/j.jsb.2019.03.006. PMID:30890426<ref>PMID:30890426</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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1RFE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RFE OCA].
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<div class="pdbe-citations 1rfe" style="background-color:#fffaf0;"></div>
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[[Category: Mycobacterium tuberculosis h37rv]]
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== References ==
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[[Category: Single protein]]
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<references/>
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[[Category: Alzari, P.]]
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__TOC__
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[[Category: Benini, S.]]
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</StructureSection>
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[[Category: Betton, J M.]]
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[[Category: Large Structures]]
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[[Category: Dodson, G G.]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Haouz, A.]]
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[[Category: Alzari P]]
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[[Category: Proux, F.]]
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[[Category: Benini S]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Betton JM]]
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[[Category: Wilson, K S.]]
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[[Category: Dodson GG]]
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[[Category: Fmn binding]]
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[[Category: Haouz A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Proux F]]
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[[Category: Protein structure initiative]]
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[[Category: Wilson KS]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Tb]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:25:47 2008''
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Current revision

Crystal structure of conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis

PDB ID 1rfe

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