8x2k
From Proteopedia
(Difference between revisions)
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| - | == | + | ==OEA bound GPR3-Gs complex structure== |
<StructureSection load='8x2k' size='340' side='right'caption='[[8x2k]], [[Resolution|resolution]] 3.03Å' scene=''> | <StructureSection load='8x2k' size='340' side='right'caption='[[8x2k]], [[Resolution|resolution]] 3.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8x2k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X2K FirstGlance]. <br> | <table><tr><td colspan='2'>[[8x2k]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X2K FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.03Å</td></tr> | ||
| - | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YM:(Z)-N-(2-hydroxyethyl)octadec-9-enamide'>5YM</scene></td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5YM:(~{Z})-~{N}-(2-hydroxyethyl)octadec-9-enamide'>5YM</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x2k OCA], [https://pdbe.org/8x2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x2k RCSB], [https://www.ebi.ac.uk/pdbsum/8x2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x2k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x2k OCA], [https://pdbe.org/8x2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x2k RCSB], [https://www.ebi.ac.uk/pdbsum/8x2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x2k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/GPR3_HUMAN GPR3_HUMAN] Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways. Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (By similarity).[UniProtKB:P35413]<ref>PMID:19213921</ref> <ref>PMID:34048700</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function. | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
OEA bound GPR3-Gs complex structure
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Categories: Homo sapiens | Large Structures | Geng C | Jun X | Yang D
