7l15
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l15 OCA], [https://pdbe.org/7l15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l15 RCSB], [https://www.ebi.ac.uk/pdbsum/7l15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l15 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7l15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7l15 OCA], [https://pdbe.org/7l15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7l15 RCSB], [https://www.ebi.ac.uk/pdbsum/7l15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7l15 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | alphabeta and gammadelta T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of gammamuTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vgamma-Cgamma) gamma-chain paired to a three-domain (Vmu-Vmuj-Cmu) mu-chain. gammamuTCRs were characterized by restricted diversity in the Vgamma and Vmuj domains and a highly diverse unpaired Vmu domain. Crystal structures of two distinct gammamuTCRs revealed the structural basis of the association of the gammamuTCR heterodimer. The Vmu domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3mu loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the gammamuTCR. | ||
| + | |||
| + | The molecular assembly of the marsupial gammamu T cell receptor defines a third T cell lineage.,Morrissey KA, Wegrecki M, Praveena T, Hansen VL, Bu L, Sivaraman KK, Darko S, Douek DC, Rossjohn J, Miller RD, Le Nours J Science. 2021 Mar 26;371(6536):1383-1388. doi: 10.1126/science.abe7070. PMID:33766885<ref>PMID:33766885</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7l15" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[T-cell receptor 3D structures|T-cell receptor 3D structures]] | *[[T-cell receptor 3D structures|T-cell receptor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Marsupial T cell receptor Spl_118
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