7xcb
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xcb OCA], [https://pdbe.org/7xcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xcb RCSB], [https://www.ebi.ac.uk/pdbsum/7xcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xcb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xcb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xcb OCA], [https://pdbe.org/7xcb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xcb RCSB], [https://www.ebi.ac.uk/pdbsum/7xcb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xcb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IL9_MOUSE IL9_MOUSE] Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327).<ref>PMID:10464327</ref> <ref>PMID:11070175</ref> <ref>PMID:12704113</ref> <ref>PMID:19433802</ref> <ref>PMID:2145361</ref> <ref>PMID:7718508</ref> | ||
==See Also== | ==See Also== | ||
*[[Interleukin 3D structures|Interleukin 3D structures]] | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of the mouse interleukin-9
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