9epo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==High resolution structure of FZD7 in inactive conformation== | |
| - | + | <StructureSection load='9epo' size='340' side='right'caption='[[9epo]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9epo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EPO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9epo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9epo OCA], [https://pdbe.org/9epo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9epo RCSB], [https://www.ebi.ac.uk/pdbsum/9epo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9epo ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FZD7_HUMAN FZD7_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adebali O]] | ||
| + | [[Category: Bous J]] | ||
| + | [[Category: Gratz L]] | ||
| + | [[Category: Kinsolving J]] | ||
| + | [[Category: Scharf MM]] | ||
| + | [[Category: Schulte G]] | ||
| + | [[Category: Selcuk B]] | ||
| + | [[Category: Voss J]] | ||
Current revision
High resolution structure of FZD7 in inactive conformation
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Categories: Homo sapiens | Large Structures | Adebali O | Bous J | Gratz L | Kinsolving J | Scharf MM | Schulte G | Selcuk B | Voss J
