7zp0
From Proteopedia
(Difference between revisions)
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</table> | </table> | ||
== Function == | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ | + | [https://www.uniprot.org/uniprot/A0A140NBW3_ECOBD A0A140NBW3_ECOBD] Member of a two-component regulatory system.[RuleBase:RU364088] |
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The CusS histidine kinase is a member of Escherichia coli two-component signal transduction system, engaged in a response to copper ions excess in the cell periplasm. The periplasmic sensor domain of CusS binds the free copper ions and the CusS kinase core phosphorylates the cognate CusR which regulates transcription of the efflux pomp CusCBA. A small amount of copper ions is indispensable for the aerobic cell metabolism. Nonetheless, its excess in the cytoplasm generates damaging and reactive hydroxyl radicals. For that reason, understanding the bacterial copper sensing mechanisms can contribute to reducing bacterial copper-resistance and developing bactericidal copper-based materials. The crystal structure of the CusS kinase core was solved at the resolution of 1.4 A. The cytoplasmic catalytic core domains formed a homodimer. Based on the obtained structure, the intramolecular and intermolecular interactions crucial for the mechanism of CusS autophosphorylation were described. | ||
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| + | Crystal structure of the Escherichia coli CusS kinase core.,Cociurovscaia A, Bujacz G, Pietrzyk-Brzezinska AJ J Struct Biol. 2022 Sep;214(3):107883. doi: 10.1016/j.jsb.2022.107883. Epub 2022 , Jul 27. PMID:35907487<ref>PMID:35907487</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7zp0" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
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[[Category: Bujacz G]] | [[Category: Bujacz G]] | ||
[[Category: Cociurovscaia A]] | [[Category: Cociurovscaia A]] | ||
| - | [[Category: Pietrzyk- | + | [[Category: Pietrzyk-Brzezinska A]] |
Current revision
Crystal structure of CusS histidine kinase catalytic core from Escherichia coli
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