Tau-tubulin kinase
From Proteopedia
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== Function == | == Function == | ||
| - | Tau-tubulin kinase (TTBK) phosphorylates microtubule-associated protein tau and tubulin<ref>PMID:24808823</ref>. TTBK contains 2 isomers: TTBK1 and TTBK2 which are expressed in different tissues. TTBK1 and TTBK2 are homologous in their catalytic domains with identical catalytic residues, but different in their non-catalytic domains. TTBK2 serves a critical function in cilia genesis<ref>PMID:25950000</ref>. | + | '''Tau-tubulin kinase''' (TTBK) phosphorylates microtubule-associated protein tau and tubulin<ref>PMID:24808823</ref>. TTBK contains 2 isomers: '''TTBK1''' and '''TTBK2''' which are expressed in different tissues. TTBK1 and TTBK2 are homologous in their catalytic domains with identical catalytic residues, but different in their non-catalytic domains. TTBK2 serves a critical function in cilia genesis<ref>PMID:25950000</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | TTBK1 inhibitors are promising candidates for Alzheimer Disease therapy<ref>PMID:37621404</ref>. | + | TTBK1 inhibitors are promising candidates for Alzheimer Disease therapy<ref>PMID:37621404</ref>. TTBK1 phosphorylates TDP-43 and thus its inhibitors can be promising therapeutic targets for treatment of ALS<ref>PMID:34978799</ref>. |
== Structural highlights == | == Structural highlights == | ||
| - | TTBK1 inhibitor interacts with residues which are in the ATP-binding pocket of the protein<ref>PMID:24039150</ref>. | + | <scene name='10/1042598/Cv/4'>TTBK1 inhibitor interacts with residues which are in the ATP-binding pocket of the protein</scene><ref>PMID:24039150</ref>. |
==Tau-tubulin kinase 3D structures== | ==Tau-tubulin kinase 3D structures== | ||
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