Melanoma-associated antigen

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> This is a default text for your page '''Melanoma-associated antigen'''. Click above on...)
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<StructureSection load='7uoa' size='340' side='right' caption='Human MAGEA4 MAGE homology domain (grey) complex with peptide inhibitor (green), ethanediol, ethylene glycol and TRIS (PDB id [[7uoa]])' scene='10/1042609/Cv/1'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 
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This is a default text for your page '''Melanoma-associated antigen'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
 
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
 
== Function ==
== Function ==
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'''Melanoma-associated antigen''' (MAGE) are produced by melanoma and recognized by cytotoxic T lymphocytes<ref>PMID:9740505</ref>.
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'''Melanoma-associated antigen''' (MAGE) are produced by tumor cells and are recognized by cytotoxic T lymphocytes<ref>PMID:9740504</ref>. Many such antigens have been identified and are classified into 2 groups with group I called cancer/testis antigens<ref>PMID:15222021</ref>. The loss of MAGE expression is observed in primary melanoma<ref>PMID:14676635</ref>.
== Disease ==
== Disease ==
== Relevance ==
== Relevance ==
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The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer<ref>PMID:17611652</ref>. Assessment of MAGE may provide stratification factor for active-specific immunotherapy<ref>PMID:12543800</ref>.
== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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The 3D structure of the complex between MAGE-A4 and the peptide inhibitor shows the peptide to bind in a cyclic conformation. The <scene name='10/1042609/Cv/3'>peptide is anchored by 3 of its residues</scene> interacting with MAGE hydrophobic pocket. MAGE residue <scene name='10/1042609/Cv/5'>M161 makes Met-aromatic interactions with 2 of the peptide Tyr residues</scene>. Additional <scene name='10/1042609/Cv/6'>H-bonds</scene> are formed between the peptide inhibitor and MAGE<ref>PMID:35522528</ref>.
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==3D structures of melanoma-associated antigen==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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MAGE; Domains: MAGE homology 101-317; PWWP 405-538
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[[3pmi]] – hMAGE1 PWWP domain (mutant) – human <BR />
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[[4v0p]] – hMAGEA3 MAGE homology domain <BR />
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[[8t9a]] – hMAGEA3 MAGE homology domain + DDB1-DCAF12 – Cryo EM<BR />
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[[2wa0]] – hMAGEA4 MAGE homology domain <BR />
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[[7uoa]] – hMAGEA4 MAGE homology domain + peptide inhibitor<BR />
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[[6r7t]] – hMAGEB1 MAGE homology domain + nanobody <BR />
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[[5hvq]], [[5wy5]] – hMAGEG1 MAGE homology domain + NSE-1<BR />
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[[6xr0]] – hMAGEP97 + antibody <BR />
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[[Category:Topic Page]]
</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

Human MAGEA4 MAGE homology domain (grey) complex with peptide inhibitor (green), ethanediol, ethylene glycol and TRIS (PDB id 7uoa)

Drag the structure with the mouse to rotate

References

  1. ↑ Kirkin AF, Dzhandzhugazyan K, Zeuthen J. Melanoma-associated antigens recognized by cytotoxic T lymphocytes. APMIS. 1998 Jul;106(7):665-79. PMID:9740504 doi:10.1111/j.1699-0463.1998.tb00210.x
  2. ↑ Xiao J, Chen HS. Biological functions of melanoma-associated antigens. World J Gastroenterol. 2004 Jul 1;10(13):1849-53. PMID:15222021 doi:10.3748/wjg.v10.i13.1849
  3. ↑ Hofbauer GF, Burkhart A, Schüler G, Dummer R, Burg G, Nestle FO. High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma. J Immunother. 2004 Jan-Feb;27(1):73-8. PMID:14676635 doi:10.1097/00002371-200401000-00007
  4. ↑ Suzuki T, Yoshida K, Wada Y, Hamai Y, Sentani K, Oue N, Yasui W. Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer. Oncol Rep. 2007 Aug;18(2):329-36 PMID:17611652
  5. ↑ Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS. Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res. 2003 Jan 15;63(2):441-8 PMID:12543800
  6. ↑ Fleming MC, Chiou LF, Tumbale PP, Droby GN, Lim J, Norris-Drouin JL, Williams JG, Pearce KH, Williams RS, Vaziri C, Bowers AA. Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4. J Med Chem. 2022 May 26;65(10):7231-7245. doi: 10.1021/acs.jmedchem.2c00185. Epub, 2022 May 6. PMID:35522528 doi:http://dx.doi.org/10.1021/acs.jmedchem.2c00185

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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