9bd1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==beta/alpha1 region of ApoB 100== |
| - | + | <StructureSection load='9bd1' size='340' side='right'caption='[[9bd1]], [[Resolution|resolution]] 5.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9bd1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BD1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bd1 OCA], [https://pdbe.org/9bd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bd1 RCSB], [https://www.ebi.ac.uk/pdbsum/9bd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bd1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Homozygous familial hypercholesterolemia. The disease is caused by variants affecting the gene represented in this entry. Most cases of FHBL1 result from nonsense mutations in the APOB gene that lead to a premature stop codon, which generate prematurely truncated apo B protein products (PubMed:21981844).<ref>PMID:21981844</ref> The disease is caused by variants affecting the gene represented in this entry. Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/APOB_HUMAN APOB_HUMAN] Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dearborn AD]] | ||
| + | [[Category: Graziano G]] | ||
| + | [[Category: Kumar A]] | ||
| + | [[Category: Lei H]] | ||
| + | [[Category: Marcotrigiano J]] | ||
| + | [[Category: Neufeld EB]] | ||
| + | [[Category: Reimund M]] | ||
| + | [[Category: Remaley AT]] | ||
Current revision
beta/alpha1 region of ApoB 100
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Categories: Homo sapiens | Large Structures | Dearborn AD | Graziano G | Kumar A | Lei H | Marcotrigiano J | Neufeld EB | Reimund M | Remaley AT
