9exj
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Aspergillus fumigatus AA11 Lytic Polysaccharide Monooxygenase (AfAA11B) in complex with Cu(II)== | |
| - | + | <StructureSection load='9exj' size='340' side='right'caption='[[9exj]], [[Resolution|resolution]] 1.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9exj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus_Af293 Aspergillus fumigatus Af293]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EXJ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9exj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9exj OCA], [https://pdbe.org/9exj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9exj RCSB], [https://www.ebi.ac.uk/pdbsum/9exj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9exj ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LP11B_ASPFU LP11B_ASPFU] Lytic polysaccharide monooxygenase (LPMO)-like protein that acts as a strict peroxygenase and does not catalyze a monooxygenase reaction (PubMed:34567832). It is indeed hardly active on chitin, while being very active on soluble oligomers of N-acetylglucosamine (PubMed:34567832). Cleaves the glycosidic bonds byoxidizing the C1 position (PubMed:34567832). Also unable to oxidize cellopentaose (PubMed:34738811). Probably breaks glycosidic bonds in non-polymeric substrates possibly carbohydrates in the cell wall of the fungus or its competitors (PubMed:34567832). In the presence of chitotetraose, the enzyme can withstand considerable amounts of H(2)O(2), which it uses to efficiently and stoichiometrically convert this substrate (PubMed:34567832).<ref>PMID:34567832</ref> <ref>PMID:34738811</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aspergillus fumigatus Af293]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ayuso-Fernandez I]] | ||
| + | [[Category: Dalleywater EL]] | ||
| + | [[Category: Englund ANB]] | ||
| + | [[Category: Golten O]] | ||
| + | [[Category: Hall KR]] | ||
| + | [[Category: Rieder L]] | ||
| + | [[Category: Rohr AK]] | ||
| + | [[Category: Ronnekleiv SE]] | ||
| + | [[Category: Skaali R]] | ||
| + | [[Category: Sorlie M]] | ||
Current revision
Crystal structure of Aspergillus fumigatus AA11 Lytic Polysaccharide Monooxygenase (AfAA11B) in complex with Cu(II)
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