8j2g
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j2g OCA], [https://pdbe.org/8j2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j2g RCSB], [https://www.ebi.ac.uk/pdbsum/8j2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j2g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j2g OCA], [https://pdbe.org/8j2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j2g RCSB], [https://www.ebi.ac.uk/pdbsum/8j2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j2g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/ZNT1_HUMAN ZNT1_HUMAN] Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity (PubMed:31471319). Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them (PubMed:32441444).[UniProtKB:Q62720]<ref>PMID:31471319</ref> <ref>PMID:32441444</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Human ZnT1-D47N/D255N mutant
| |||||||||||
Categories: Homo sapiens | Large Structures | He B | Liu X | Sun C | Sun L
