9ew4

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'''Unreleased structure'''
 
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The entry 9ew4 is ON HOLD until Paper Publication
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==Ternary structure of 14-3-3s, C-RAF phosphopeptide 12mer (pS259) and compound 86 (1124384)==
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<StructureSection load='9ew4' size='340' side='right'caption='[[9ew4]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Konstantinidou, M., Vickery, H., Pennings, M.A.M., Virta, J., Visser, E.J., Oetelaar, M.C.M., Overmans, M., Neitz, J., Ottmann, C., Brunsveld, L., Arkin, M.R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ew4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EW4 FirstGlance]. <br>
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Description: Ternary structure of 14-3-3s, C-RAF phosphopeptide 12mer (pS259) and compound 86 (1124384)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=WQ9:1-[(5~{R})-2-(4-bromanyl-3-fluoranyl-phenyl)sulfonyl-2,7-diazaspiro[4.4]nonan-7-yl]-2-chloranyl-ethanone'>WQ9</scene></td></tr>
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[[Category: Konstantinidou, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ew4 OCA], [https://pdbe.org/9ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ew4 ProSAT]</span></td></tr>
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[[Category: Virta, J]]
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</table>
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[[Category: Overmans, M]]
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== Function ==
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[[Category: Ottmann, C]]
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[[Category: Neitz, J]]
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__TOC__
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[[Category: Arkin, M.R]]
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</StructureSection>
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[[Category: Visser, E.J]]
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[[Category: Homo sapiens]]
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[[Category: Pennings, M.A.M]]
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[[Category: Large Structures]]
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[[Category: Brunsveld, L]]
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[[Category: Arkin MR]]
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[[Category: Oetelaar, M.C.M]]
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[[Category: Brunsveld L]]
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[[Category: Vickery, H]]
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[[Category: Konstantinidou M]]
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[[Category: Neitz J]]
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[[Category: Oetelaar MCM]]
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[[Category: Ottmann C]]
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[[Category: Overmans M]]
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[[Category: Pennings MAM]]
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[[Category: Vickery H]]
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[[Category: Virta J]]
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[[Category: Visser EJ]]

Current revision

Ternary structure of 14-3-3s, C-RAF phosphopeptide 12mer (pS259) and compound 86 (1124384)

PDB ID 9ew4

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OCA

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