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8t4d
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t4d OCA], [https://pdbe.org/8t4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t4d RCSB], [https://www.ebi.ac.uk/pdbsum/8t4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t4d ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t4d OCA], [https://pdbe.org/8t4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t4d RCSB], [https://www.ebi.ac.uk/pdbsum/8t4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t4d ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Germline-targeting immunogens hold promise for initiating the induction of broadly neutralizing antibodies (bnAbs) to HIV and other pathogens. However, antibody-antigen recognition is typically dominated by heavy chain complementarity determining region 3 (HCDR3) interactions, and vaccine priming of HCDR3-dominant bnAbs by germline-targeting immunogens has not been demonstrated in humans or outbred animals. In this work, immunization with N332-GT5, an HIV envelope trimer designed to target precursors of the HCDR3-dominant bnAb BG18, primed bnAb-precursor B cells in eight of eight rhesus macaques to substantial frequencies and with diverse lineages in germinal center and memory B cells. We confirmed bnAb-mimicking, HCDR3-dominant, trimer-binding interactions with cryo-electron microscopy. Our results demonstrate proof of principle for HCDR3-dominant bnAb-precursor priming in outbred animals and suggest that N332-GT5 holds promise for the induction of similar responses in humans. | ||
| + | |||
| + | , PMID:38753769<ref>PMID:38753769</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 8t4d" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
MD65 N332-GT5 SOSIP in complex with RM_N332_08 Fab and RM20A3 Fab
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