1rz8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (04:52, 17 October 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1rz8.gif|left|200px]]
 
-
<!--
+
==CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B==
-
The line below this paragraph, containing "STRUCTURE_1rz8", creates the "Structure Box" on the page.
+
<StructureSection load='1rz8' size='340' side='right'caption='[[1rz8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1rz8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz8 OCA], [https://pdbe.org/1rz8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz8 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz8 ProSAT]</span></td></tr>
-
{{STRUCTURE_1rz8| PDB=1rz8 | SCENE= }}
+
</table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz8 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
-
'''CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B'''
+
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>
-
 
+
-
 
+
-
==Overview==
+
-
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
+
-
==About this Structure==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ8 OCA].
+
</div>
 +
<div class="pdbe-citations 1rz8" style="background-color:#fffaf0;"></div>
-
==Reference==
+
==See Also==
-
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
+
*[[Antibody 3D structures|Antibody 3D structures]]
-
[[Category: Choe, H.]]
+
*[[Sandbox 20009|Sandbox 20009]]
-
[[Category: Dimitrov, D S.]]
+
*[[3D structures of human antibody|3D structures of human antibody]]
-
[[Category: Farzan, M.]]
+
== References ==
-
[[Category: Hendrickson, W A.]]
+
<references/>
-
[[Category: Huang, C C.]]
+
__TOC__
-
[[Category: Kwong, P D.]]
+
</StructureSection>
-
[[Category: Majeed, S.]]
+
[[Category: Homo sapiens]]
-
[[Category: Moore, M J.]]
+
[[Category: Large Structures]]
-
[[Category: Phogat, S.]]
+
[[Category: Choe H]]
-
[[Category: Robinson, J.]]
+
[[Category: Dimitrov DS]]
-
[[Category: Sodroski, J.]]
+
[[Category: Farzan M]]
-
[[Category: Venturi, M.]]
+
[[Category: Hendrickson WA]]
-
[[Category: Wyatt, R.]]
+
[[Category: Huang CC]]
-
[[Category: Zhang, M Y.]]
+
[[Category: Kwong PD]]
-
[[Category: Antibody]]
+
[[Category: Majeed S]]
-
[[Category: Cd4i]]
+
[[Category: Moore MJ]]
-
[[Category: Gp120]]
+
[[Category: Phogat S]]
-
[[Category: Hiv-1]]
+
[[Category: Robinson J]]
-
[[Category: Tyrosine sulfation]]
+
[[Category: Sodroski J]]
-
[[Category: Vh-gene usage]]
+
[[Category: Venturi M]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:05:41 2008''
+
[[Category: Wyatt R]]
 +
[[Category: Zhang M-Y]]

Current revision

CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B

PDB ID 1rz8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rz8"
Personal tools