1rzf

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[[Image:1rzf.gif|left|200px]]
 
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==Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51==
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The line below this paragraph, containing "STRUCTURE_1rzf", creates the "Structure Box" on the page.
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<StructureSection load='1rzf' size='340' side='right'caption='[[1rzf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rzf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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{{STRUCTURE_1rzf| PDB=1rzf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rzf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzf OCA], [https://pdbe.org/1rzf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rzf RCSB], [https://www.ebi.ac.uk/pdbsum/1rzf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rzf ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rzf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
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'''Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51'''
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>
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==Overview==
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The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZF OCA].
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</div>
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<div class="pdbe-citations 1rzf" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14981267 14981267]
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*[[Antibody 3D structures|Antibody 3D structures]]
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[[Category: Choe, H.]]
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*[[Sandbox 20009|Sandbox 20009]]
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[[Category: Dimitrov, D S.]]
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*[[3D structures of human antibody|3D structures of human antibody]]
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[[Category: Farzan, M.]]
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== References ==
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[[Category: Hendrickson, W A.]]
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<references/>
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[[Category: Huang, C C.]]
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__TOC__
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[[Category: Kwong, P D.]]
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</StructureSection>
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[[Category: Majeed, S.]]
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[[Category: Homo sapiens]]
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[[Category: Moore, M J.]]
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[[Category: Large Structures]]
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[[Category: Phogat, S.]]
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[[Category: Choe H]]
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[[Category: Robinson, J.]]
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[[Category: Dimitrov DS]]
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[[Category: Sodroski, J.]]
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[[Category: Farzan M]]
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[[Category: Venturi, M.]]
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[[Category: Hendrickson WA]]
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[[Category: Wyatt, R.]]
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[[Category: Huang CC]]
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[[Category: Zhang, M Y.]]
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[[Category: Kwong PD]]
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[[Category: Antibody]]
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[[Category: Majeed S]]
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[[Category: Cd4i]]
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[[Category: Moore MJ]]
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[[Category: Gp120]]
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[[Category: Phogat S]]
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[[Category: Hiv-1]]
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[[Category: Robinson J]]
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[[Category: Tyrosine sulfation]]
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[[Category: Sodroski J]]
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[[Category: Vh-gene usage]]
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[[Category: Venturi M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:06:06 2008''
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[[Category: Wyatt R]]
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[[Category: Zhang M-Y]]

Current revision

Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51

PDB ID 1rzf

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