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1s2r

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[[Image:1s2r.gif|left|200px]]
 
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==A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2==
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The line below this paragraph, containing "STRUCTURE_1s2r", creates the "Structure Box" on the page.
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<StructureSection load='1s2r' size='340' side='right'caption='[[1s2r]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s2r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S2R FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>
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{{STRUCTURE_1s2r| PDB=1s2r | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2r OCA], [https://pdbe.org/1s2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s2r RCSB], [https://www.ebi.ac.uk/pdbsum/1s2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s2r ProSAT]</span></td></tr>
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</table>
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'''A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Howerton SB]]
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The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a monolayer of solvent sites, including a "spine of hydration", is visible in the minor groove. The crystal of [d(CGCAAATTTGCG)]2 was grown from a solution containing spermine, magnesium, and lithium. The conformation recapitulates that of "monovalent-minus" DNA.
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[[Category: Maehigashi T]]
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[[Category: Tannenbaum S]]
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==About this Structure==
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[[Category: Williams LD]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2R OCA].
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[[Category: Woods KK]]
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==Reference==
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High-resolution structure of an extended A-tract: [d(CGCAAATTTGCG)]2., Woods KK, Maehigashi T, Howerton SB, Sines CC, Tannenbaum S, Williams LD, J Am Chem Soc. 2004 Dec 1;126(47):15330-1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15563130 15563130]
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[[Category: Howerton, S B.]]
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[[Category: Maehigashi, T.]]
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[[Category: Tannenbaum, S.]]
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[[Category: Williams, L D.]]
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[[Category: Woods, K K.]]
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[[Category: Dodecamer]]
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[[Category: Minor groove hydration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:13:28 2008''
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Current revision

A High Resolution Crystal Structure of [d(CGCAAATTTGCG)]2

PDB ID 1s2r

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