9f7k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Glutathione transferase epsilon 1 from Drosophila melanogaster in complex with glutathione== | |
| + | <StructureSection load='9f7k' size='340' side='right'caption='[[9f7k]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9f7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster_American_nodavirus_(ANV)_SW-2009a Drosophila melanogaster American nodavirus (ANV) SW-2009a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F7K FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f7k OCA], [https://pdbe.org/9f7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f7k RCSB], [https://www.ebi.ac.uk/pdbsum/9f7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f7k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q7KK90_DROME Q7KK90_DROME] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | This study presents a comprehensive analysis of the dimerization interfaces of fly GSTs through sequence alignment. Our investigation revealed GSTE1 as a particularly intriguing target, providing valuable insights into the variations within Delta and Epsilon GST interfaces. The X-ray structure of GSTE1 was determined, unveiling remarkable thermal stability and a distinctive dimerization interface. Utilizing circular dichroism, we assessed the thermal stability of GSTE1 and other Drosophila GSTs with resolved X-ray structures. The subsequent examination of GST dimer stability correlated with the dimerization interface supported by findings from X-ray structural analysis and thermal stability measurements. Our discussion extends to the broader context of GST dimer interfaces, offering a generalized perspective on their stability. This research enhances our understanding of the structural and thermodynamic aspects of GST dimerization, contributing valuable insights to the field. | ||
| - | + | Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases.,Schwartz M, Petiot N, Chaloyard J, Senty-Segault V, Lirussi F, Senet P, Nicolai A, Heydel JM, Canon F, Sonkaria S, Khare V, Didierjean C, Neiers F Biomolecules. 2024 Jun 26;14(7):758. doi: 10.3390/biom14070758. PMID:39062472<ref>PMID:39062472</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 9f7k" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Didierjean C]] | ||
| + | [[Category: Neiers F]] | ||
| + | [[Category: Schwartz M]] | ||
Current revision
Glutathione transferase epsilon 1 from Drosophila melanogaster in complex with glutathione
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