9f9l

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(New page: '''Unreleased structure''' The entry 9f9l is ON HOLD Authors: Collie, G.W. Description: Crystal structure of MUS81-EME1 bound by compound 16. Category: Unreleased Structures [[Cate...)
Current revision (07:24, 3 July 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9f9l is ON HOLD
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==Crystal structure of MUS81-EME1 bound by compound 16.==
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<StructureSection load='9f9l' size='340' side='right'caption='[[9f9l]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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Authors: Collie, G.W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9f9l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9F9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9F9L FirstGlance]. <br>
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Description: Crystal structure of MUS81-EME1 bound by compound 16.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IA8:2-[2-[4-(cyanomethyl)phenyl]phenyl]-5-oxidanyl-6-oxidanylidene-1H-pyrimidine-4-carboxylic+acid'>A1IA8</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Collie, G.W]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9f9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9f9l OCA], [https://pdbe.org/9f9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9f9l RCSB], [https://www.ebi.ac.uk/pdbsum/9f9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9f9l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Collie GW]]

Current revision

Crystal structure of MUS81-EME1 bound by compound 16.

PDB ID 9f9l

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