1s4j

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[[Image:1s4j.gif|left|200px]]
 
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==NMR structure of cross-reactive peptides from Homo sapiens==
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The line below this paragraph, containing "STRUCTURE_1s4j", creates the "Structure Box" on the page.
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<StructureSection load='1s4j' size='340' side='right'caption='[[1s4j]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s4j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4j OCA], [https://pdbe.org/1s4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4j RCSB], [https://www.ebi.ac.uk/pdbsum/1s4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4j ProSAT]</span></td></tr>
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{{STRUCTURE_1s4j| PDB=1s4j | SCENE= }}
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</table>
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== Function ==
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'''NMR structure of cross-reactive peptides from Homo sapiens'''
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[https://www.uniprot.org/uniprot/RLA2_HUMAN RLA2_HUMAN] Plays an important role in the elongation step of protein synthesis.[HAMAP-Rule:MF_01478]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid difference between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2beta protein was probed by transferred NOE. The results show that the flexibility of R13 is fundamental for the binding to the antibody.
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==About this Structure==
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Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis.,Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:14988012<ref>PMID:14988012</ref>
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1S4J is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4J OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Correlation between conformation and antibody binding: NMR structure of cross-reactive peptides from T. cruzi, human and L. braziliensis., Soares MR, Bisch PM, Campos de Carvalho AC, Valente AP, Almeida FC, FEBS Lett. 2004 Feb 27;560(1-3):134-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14988012 14988012]
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</div>
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[[Category: Single protein]]
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<div class="pdbe-citations 1s4j" style="background-color:#fffaf0;"></div>
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[[Category: Almeida, F C.L.]]
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== References ==
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[[Category: Bisch, P M.]]
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<references/>
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[[Category: Carvalho, A C.Campos de.]]
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__TOC__
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[[Category: Soares, M R.]]
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</StructureSection>
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[[Category: Valente, A P.]]
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[[Category: Homo sapiens]]
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[[Category: Antigenic peptide]]
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[[Category: Large Structures]]
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[[Category: Chagas disease]]
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[[Category: Almeida FCL]]
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[[Category: Ribosomal p2 protein]]
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[[Category: Bisch PM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:17:21 2008''
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[[Category: Campos de Carvalho AC]]
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[[Category: Soares MR]]
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[[Category: Valente AP]]

Current revision

NMR structure of cross-reactive peptides from Homo sapiens

PDB ID 1s4j

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