Activin receptor

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3D structure of the kinase domain of Acvr1 complex with inhibitor shows <scene name='84/843934/Cv/3'>the inhibitor forming various interactions</scene> with the protein including a <scene name='84/843934/Cv/5'>hydrogen bonds to His residues</scene> and a <scene name='84/843934/Cv/6'>water bridged hydrogen bond to the catalytic lysine</scene><ref>PMID:25101911</ref>. Water molecule is shown as red sphere.
3D structure of the kinase domain of Acvr1 complex with inhibitor shows <scene name='84/843934/Cv/3'>the inhibitor forming various interactions</scene> with the protein including a <scene name='84/843934/Cv/5'>hydrogen bonds to His residues</scene> and a <scene name='84/843934/Cv/6'>water bridged hydrogen bond to the catalytic lysine</scene><ref>PMID:25101911</ref>. Water molecule is shown as red sphere.
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</StructureSection>
 
==3D structures of activin receptor==
==3D structures of activin receptor==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Activin receptor 3D structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Activin receptor type 1 or Activin receptor-like type 2 or Serine/threonine-protein kinase receptor R1 or ALK2 or BMP type 1 receptor kinase
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**[[5oxg]] - hAcvr1 kinase domain 172-499 + inhibitor - human<br />
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**[[6acr]], [[6gi6]], [[6gip]], [[6gin]], [[4bgg]], [[3q4u]], [[3mtf]], [[6t6d]], [[6jux]], [[6tnb]], [[6tn8]], [[6t8n]], [[6szm]], [[6eix]], [[6srh]], [[5oy6]], [[6z36]], [[6zgc]], [[7a21]], [[7c3g]] - hAcvr1 kinase domain (mutant) + inhibitor<br />
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**[[3h9r]], [[4c02]], [[6i1s]] - hAcvr1 kinase domain + FKBP12 + inhibitor<br />
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**[[7nns]] - hAcvr1 kinase domain + drug<br />
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*Activin receptor type 2
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**[[1bte]] - Acvr2 LBD 19-134 - mouse<br />
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*Activin receptor type 2A
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**[[4asx]], [[3soc]], [[3q4t]] - hAcvr2A kinase domain + inhibitor<br />
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**[[5nh3]] - hAcvr2A LBD + antibody<br />
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**[[7u5p]] - hAcvr2A LBD + inhibin<br />
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**[[2goo]], [[2h64]], [[2h62]] - mAcvr2A LBD + BMP-2 + ALK3<br />
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**[[1lx5]] - mAcvr2A LBD + BMP-7<br />
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*Activin receptor type 2B
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**[[2qlu]] - hAcvr2B kinase domain<br />
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**[[5ngv]], [[5nhr]] - hAcvr2B LBD + antibody<br />
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**[[7oly]] - hAcvr2B LBD + hAcvr1B LBD + antibody + inhibin<br />
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**[[7mrz]] - hAcvr2B LBD + hAcvr1B LBD + antibody + GDF11<br />
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**[[1s4y]] - mAcvr2B LBD + inhibin<br />
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**[[1nyu]] - rAcvr2B LBD + inhibin - rat<br />
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**[[6mac]] - rAcvr2B LBD + GDF-11 + ALK5<br />
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*Activin receptor-like type 1 or Serine/threonine-protein kinase receptor R3 or ALK1
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**[[2lcr]] - hALK1 LBD - NMR<br />
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**[[6sf2]] - hALK1 LBD + GDF-2<br />
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**[[4fao]] - hALK1 LBD + GDF-2 + SKR3<br />
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**[[6sf1]], [[6sf3]] - hALK1 LBD + BMP10<br />
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**[[3my0]] - hALK1 kinase domain + inhibitor<br />
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}}
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== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Human Acvr1 kinase domain complex with inhibitor, ethylene glycol and citrate (PDB code 4bgg)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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