8zkw

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'''Unreleased structure'''
 
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The entry 8zkw is ON HOLD
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==Cryo-EM structure of the Drosophila INDY (apo-asymmetric, pH 6)==
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<StructureSection load='8zkw' size='340' side='right'caption='[[8zkw]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
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Authors: Kim, S., Park, J.G., Choi, S.H., Kim, J.W., Jin, M.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8zkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ZKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ZKW FirstGlance]. <br>
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Description: Cryo-EM structure of the Drosophila INDY (apo-asymmetric, pH 6)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
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[[Category: Kim, S]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8zkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8zkw OCA], [https://pdbe.org/8zkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8zkw RCSB], [https://www.ebi.ac.uk/pdbsum/8zkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8zkw ProSAT]</span></td></tr>
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[[Category: Park, J.G]]
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</table>
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[[Category: Jin, M.S]]
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== Function ==
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[[Category: Kim, J.W]]
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[https://www.uniprot.org/uniprot/INDY1_DROME INDY1_DROME] Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na(+), K(+), or Cl(-). Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.<ref>PMID:11118146</ref> <ref>PMID:12186628</ref> <ref>PMID:12391301</ref>
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[[Category: Choi, S.H]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Drosophila melanogaster]]
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[[Category: Large Structures]]
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[[Category: Choi SH]]
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[[Category: Jin MS]]
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[[Category: Kim JW]]
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[[Category: Kim S]]
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[[Category: Park JG]]

Current revision

Cryo-EM structure of the Drosophila INDY (apo-asymmetric, pH 6)

PDB ID 8zkw

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