9b9t

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:14, 6 November 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9b9t is ON HOLD until Paper Publication
+
==Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407==
-
 
+
<StructureSection load='9b9t' size='340' side='right'caption='[[9b9t]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
-
Authors: Mabanglo, M.F., Hoffer, L., Al-awar, R., Vedadi, M.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9b9t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B9T FirstGlance]. <br>
-
Description: Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ANM:~{N}-[5-[5-[2-[2-[2-[2-[2-[2-[4-[4-[[(1~{S})-3-azanyl-1-(3-chloranyl-4-fluoranyl-phenyl)-3-oxidanylidene-propyl]carbamoyl]-3-(4-chloranyl-2-fluoranyl-phenyl)-1~{H}-pyrrol-2-yl]pyrazol-1-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]-2-fluoranyl-phenyl]-2-[(3~{S},5~{R})-3,4,5-trimethylpiperazin-1-yl]phenyl]-6-oxidanylidene-4-(trifluoromethyl)-1~{H}-pyridine-3-carboxamide'>A1ANM</scene></td></tr>
-
[[Category: Hoffer, L]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b9t OCA], [https://pdbe.org/9b9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b9t RCSB], [https://www.ebi.ac.uk/pdbsum/9b9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b9t ProSAT]</span></td></tr>
-
[[Category: Mabanglo, M.F]]
+
</table>
-
[[Category: Vedadi, M]]
+
== Function ==
-
[[Category: Al-Awar, R]]
+
[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Al-awar R]]
 +
[[Category: Hoffer L]]
 +
[[Category: Krausser C]]
 +
[[Category: Mabanglo MF]]
 +
[[Category: Vedadi M]]
 +
[[Category: Wilson BJ]]

Current revision

Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407

PDB ID 9b9t

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9b9t"
Personal tools