9fdf

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m (Protected "9fdf" [edit=sysop:move=sysop])
Current revision (07:11, 29 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9fdf is ON HOLD
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==Human phosphoglycerate kinase in with mixture of products and substrates produced by cross-soaking a TSA crystal==
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<StructureSection load='9fdf' size='340' side='right'caption='[[9fdf]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9fdf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FDF FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=X15:1,3-BISPHOSPHOGLYCERIC+ACID'>X15</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fdf OCA], [https://pdbe.org/9fdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fdf RCSB], [https://www.ebi.ac.uk/pdbsum/9fdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fdf ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[https://omim.org/entry/300653 300653]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Baxter NJ]]
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[[Category: Bisson C]]
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[[Category: Blackburn GM]]
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[[Category: Bowler MW]]
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[[Category: Cliff MJ]]
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[[Category: Waltho JP]]

Current revision

Human phosphoglycerate kinase in with mixture of products and substrates produced by cross-soaking a TSA crystal

PDB ID 9fdf

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