1v6r
From Proteopedia
(Difference between revisions)
(New page: 200px<br /> <applet load="1v6r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1v6r" /> '''Solution Structure of Endothelin-1 with its...) |
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| - | [[Image:1v6r.gif|left|200px]]<br /> | ||
| - | <applet load="1v6r" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1v6r" /> | ||
| - | '''Solution Structure of Endothelin-1 with its C-terminal Folding'''<br /> | ||
| - | == | + | ==Solution Structure of Endothelin-1 with its C-terminal Folding== |
| + | <StructureSection load='1v6r' size='340' side='right'caption='[[1v6r]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1v6r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1V6R FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1v6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v6r OCA], [https://pdbe.org/1v6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1v6r RCSB], [https://www.ebi.ac.uk/pdbsum/1v6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1v6r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN] Endothelins are endothelium-derived vasoconstrictor peptides. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
Distributed computing has been implemented to the solution structure determination of endothelin-1 to evaluate efficiency of the method for NMR constraint-based structure calculations. A key target of the investigation was determination of the C-terminal folding of the peptide, which had been dispersed in previous studies of NMR, despite its pharmacological significances. With use of tens of thousands of random initial structures to explore the conformational space comprehensively, we determined high-resolution structures with good convergences of C-terminal as well as previously defined N-terminal structures. The previous studies had missed the C-terminal convergence because of initial structure dependencies trapped in localized folding of the N-terminal region, which are strongly constricted by two disulfide bonds. | Distributed computing has been implemented to the solution structure determination of endothelin-1 to evaluate efficiency of the method for NMR constraint-based structure calculations. A key target of the investigation was determination of the C-terminal folding of the peptide, which had been dispersed in previous studies of NMR, despite its pharmacological significances. With use of tens of thousands of random initial structures to explore the conformational space comprehensively, we determined high-resolution structures with good convergences of C-terminal as well as previously defined N-terminal structures. The previous studies had missed the C-terminal convergence because of initial structure dependencies trapped in localized folding of the N-terminal region, which are strongly constricted by two disulfide bonds. | ||
| - | + | Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding.,Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:15070353<ref>PMID:15070353</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1v6r" style="background-color:#fffaf0;"></div> |
| - | [[Category: Kobayashi | + | == References == |
| - | [[Category: Mimura | + | <references/> |
| - | [[Category: Ohkubo | + | __TOC__ |
| - | [[Category: Takashima | + | </StructureSection> |
| - | [[Category: Tamaoki | + | [[Category: Homo sapiens]] |
| - | [[Category: Yoshida | + | [[Category: Large Structures]] |
| - | + | [[Category: Kobayashi Y]] | |
| - | + | [[Category: Mimura N]] | |
| - | + | [[Category: Ohkubo T]] | |
| - | + | [[Category: Takashima H]] | |
| - | + | [[Category: Tamaoki H]] | |
| - | + | [[Category: Yoshida T]] | |
| - | + | ||
Current revision
Solution Structure of Endothelin-1 with its C-terminal Folding
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